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Applied Toxicology

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Research> Research Facilities> Applied Toxicology

CHEMICAL SAFETY & APPLIED TOXICOLOGY (CSAT) LABORATORY

The core research work undertaken by CSAT Laboratory involves the development and use of in vitro biological toxicity methods using human cells (taken from the skin, liver, lungs, blood etc…) and tissues (e.g. skin from elective surgery patients) as an entirely new approach for toxicity testing.

One of the CSAT Lab’s primary interests is the development of rapid biological test methods and toxicity testing of a wide range of compounds including:

  • industrial chemicals
  • chemical mixtures
  • pharmaceuticals
  • cosmeceuticals
  • natural products
  • contaminated sites, soil, and/or water
  • air pollution and fire combustion products etc…
The CSAT Lab provides opportunities for research students to present their experimental results at both national and international conferences, and the CSAT Lab research has been recognised internationally, having been published in peer-reviewed journals such as Toxicology, Toxicology Letters, Toxicology in vitro, Food and Chemical Toxicology, Toxicology and Industrial Health, Journal of Cosmetic Dermatology, Inhalation Toxicology and Journal of Environmental Monitoring.

The CSAT Lab offers an extensive range of equipment required for the research and development of in vitro toxicity testing. These facilities include:

  • Class II Biological Cabinets
  • Luminometer
  • Multiskan Absorbance Plate Readers for 96 and 384 well plates
  • Incubators including CO2
  • Centrifuges including refrigerated
  • Ovens
  • Franz Diffusion Cell Apparatus (Permegear) for skin absorption studies
  • Horizontal Diffusion Chamber Systems for inhalation toxicity investigations
  • Water Baths (including re-circulating)
  • Light Microscopes
  • Inverted Microscopes
  • Molecular Biology facilities: immunohistochemistry/histopathology
  • Fume hood
  • Air sampling equipment